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Last Updated: January 26, 2021

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Patent: 5,612,460

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Summary for Patent: 5,612,460
Title: Active carbonates of polyalkylene oxides for modification of polypeptides
Abstract:Poly(ethylene glycol)-N-succinimide carbonate and its preparation are disclosed. Polyethylene glycol (PEG) is converted into its N-succinimide carbonate derivative. This form of the polymer reacts readily with amino groups of proteins in aqueous buffers. The modified proteins have PEG-chains grafted onto the polypeptide backbone by means of stable, hydrolysis-resistant urethane (carbamate) linkages.
Inventor(s): Zalipsky; Shmuel (Edison, NJ)
Assignee: Enzon, Inc. (Piscataway, NJ)
Application Number:08/198,193
Patent Claims:see list of patent claims

Details for Patent 5,612,460

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial Enzon, Inc. (Piscataway, NJ) 2014-03-18 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

Boehringer Ingelheim

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