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Last Updated: September 27, 2020

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Patent: 5,585,007

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Summary for Patent: 5,585,007
Title: Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant
Abstract:An inexpensive device with a disposable cartridge for preparing tissue sealant is disclosed. The device is particularly applicable to star preparation of autologous tissue sealant. A method of sealing tissue in which the tissue sealant is applied immediately after mixing platelet-rich plasma concentrate (from the device) with a solution of calcium and thrombin is also disclosed. Preparation in the operating room of 5 cc sealant from 50 cc patient blood requires less than 15 minutes and only one simple operator step. There is no risk of tracking error because processing can be done in the operating room. Chemicals added may be limited to anticoagulant (e.g., citrate) and calcium chloride. The disposable cartridge may fit in the palm of the hand and is hermetically sealed to eliminate possible exposure to patient blood and ensure sterility. Adhesive and tensile strengths are comparable or superior to pooled blood fibrin sealants made with precipitation methods. Antifibrinolytic agents (such as aprotinin) are not necessary because the tissue sealant contains high concentrations of natural inhibitors of fibrinolysis from the patient\'s blood. The tissue sealant also contains patient platelets and additional factors not present in available fibrin sealants that promote wound healing.
Inventor(s): Antanavich; Richard D. (Paso Robles, CA), Dorian; Randel (Orinda, CA)
Assignee: PlasmaSeal Corporation (San Francisco, CA)
Application Number:08/351,010
Patent Claims:see list of patent claims

Details for Patent 5,585,007

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial PlasmaSeal Corporation (San Francisco, CA) 2039-02-26 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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