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Last Updated: September 28, 2020

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Patent: 5,578,461

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Summary for Patent: 5,578,461
Title: Gene manipulation and expression using genomic elements
Abstract:Expression of mammalian target genes is achieved by employing chromosomal target DNA, either native primary cells or YACs in a yeast host, where the YACs include a fragment of a mammalian chromosome, the fragment comprising the target gene. Employing homologous recombination, an amplifiable gene is integrated into the mammalian fragment at a site to allow for amplification. In the same step, or one or more steps, as desired, the mammalian gene and/or the transcriptional system may be modified by in vivo mutagenesis. The resulting construct from homologous recombination may then be transformed into a mammalian expression host and integrated into the host genome, either randomly or by homologous recombination. The amplifiable gene may then be amplified by an appropriate agent providing for multiple copies of the target gene and the expression host grown to provide for high yields of the desired wild-type or modified protein.
Inventor(s): Sherwin; Stephen (San Francisco, CA), Klapholz; Sue (Stanford, CA), Skoultchi; Arthur (Larchmont, NY)
Assignee: Cell Genesys, Inc. (Foster City, CA)
Application Number:08/102,567
Patent Claims:see list of patent claims

Details for Patent 5,578,461

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Cell Genesys, Inc. (Foster City, CA) 2013-11-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Cell Genesys, Inc. (Foster City, CA) 2013-11-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Cell Genesys, Inc. (Foster City, CA) 2013-11-26 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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