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Generated: July 16, 2019

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Patent: 5,571,698

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Summary for Patent: 5,571,698
Title: Directed evolution of novel binding proteins
Abstract:In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore or phage (genetic package) are introduced into a genetic package. The protein is expressed and the potential binding domain is displayed on the outer surface of the package. The cells or viruses bearing the binding domains which recognize the target molecule are isolated and amplified. The successful binding domains are then characterized. One or more of these successful binding domains is used as a model for the design of a new family of potential binding domains, and the process is repeated until a novel binding domain having a desired affinity for the target molecule is obtained. In one embodiment, the first family of potential binding domains is related to bovine pancreatic trypsin inhibitor, the genetic package is M13 phage, and the protein includes the outer surface transport signal of the M13 gene III protein.
Inventor(s): Ladner; Robert C. (Ijamsville, MD), Guterman; Sonia K. (Belmont, MA), Roberts; Bruce L. (Milford, MA), Markland; William (Milford, MA), Ley; Arthur C. (Newton, MA), Kent; Rachel B. (Boxborough, MA)
Assignee: Protein Engineering Corporation (Cambridge, MA)
Application Number:08/057,667
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 5,571,698
Patent Claims:see list of patent claims

Details for Patent 5,571,698

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Advance Biofactures SANTYL collagenase VIAL 101995 001 1965-06-04 ➤ Try a Free Trial Protein Engineering Corporation (Cambridge, MA) ➤ Try a Free Trial RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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International Patent Family for US Patent 5,571,698

Country Patent Number Publication Date
World Intellectual Property Organization (WIPO) 9002809 Mar 22, 1990
World Intellectual Property Organization (WIPO) 9206191 Apr 16, 1992
World Intellectual Property Organization (WIPO) 9215605 Dec 23, 1992
World Intellectual Property Organization (WIPO) 9215605 Sep 17, 1992
World Intellectual Property Organization (WIPO) 9215677 Sep 17, 1992
Country Patent Number Publication Date

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Cantor Fitzgerald
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Queensland Health
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