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Last Updated: September 28, 2020

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Patent: 5,545,727

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Summary for Patent: 5,545,727
Title: DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
Abstract:The alpha subunits of hemoglobin, which in nature are formed as separate polypeptide chains which bind noncovalently to the beta subunits, are here provided in the form of the novel molecule di-alpha globin, a single polypeptide chain defined by connecting the two alpha subunits either directly via peptide bond or indirectly by a flexible amino acid or peptide linker. Di-alpha globin may be combined in vivo or in vitro with beta globin and heme to form hemoglobin. Di-alpha globin is expressed by recombinant DNA techniques. Di-beta globin may be similarly obtained. DNA encoding alpha globin fusion proteins is provided.
Inventor(s): Hoffman; Stephen J. (Denver), Looker; Douglas L. (Lafayette, CO), Nagai; Kiyoshi (Cambridge, GB2)
Assignee: Somatogen, Inc. (Boulder, CO)
Application Number:07/789,179
Patent Claims:see list of patent claims

Details for Patent 5,545,727

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Somatogen, Inc. (Boulder, CO) 2013-08-13 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Somatogen, Inc. (Boulder, CO) 2013-08-13 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Somatogen, Inc. (Boulder, CO) 2013-08-13 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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