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Last Updated: March 24, 2023

Patent: 5,545,727

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Summary for Patent: 5,545,727
Title: DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
Abstract:The alpha subunits of hemoglobin, which in nature are formed as separate polypeptide chains which bind noncovalently to the beta subunits, are here provided in the form of the novel molecule di-alpha globin, a single polypeptide chain defined by connecting the two alpha subunits either directly via peptide bond or indirectly by a flexible amino acid or peptide linker. Di-alpha globin may be combined in vivo or in vitro with beta globin and heme to form hemoglobin. Di-alpha globin is expressed by recombinant DNA techniques. Di-beta globin may be similarly obtained. DNA encoding alpha globin fusion proteins is provided.
Inventor(s): Hoffman; Stephen J. (Denver), Looker; Douglas L. (Lafayette, CO), Nagai; Kiyoshi (Cambridge, GB2)
Assignee: Somatogen, Inc. (Boulder, CO)
Application Number:07/789,179
Patent Claims:see list of patent claims

Details for Patent 5,545,727

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 06/04/1986 See Plans and Pricing 2013-08-13
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 See Plans and Pricing 2013-08-13
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b Injection 103132 See Plans and Pricing 2013-08-13
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Serving leading biopharmaceutical companies globally:

Boehringer Ingelheim
Johnson and Johnson

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