Patent: 5,545,727

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Summary for Patent: 5,545,727

Title:	DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
Abstract:	The alpha subunits of hemoglobin, which in nature are formed as separate polypeptide chains which bind noncovalently to the beta subunits, are here provided in the form of the novel molecule di-alpha globin, a single polypeptide chain defined by connecting the two alpha subunits either directly via peptide bond or indirectly by a flexible amino acid or peptide linker. Di-alpha globin may be combined in vivo or in vitro with beta globin and heme to form hemoglobin. Di-alpha globin is expressed by recombinant DNA techniques. Di-beta globin may be similarly obtained. DNA encoding alpha globin fusion proteins is provided.
Inventor(s):	Hoffman; Stephen J. (Denver), Looker; Douglas L. (Lafayette, CO), Nagai; Kiyoshi (Cambridge, GB2)
Assignee:	Somatogen, Inc. (Boulder, CO)
Application Number:	07/789,179
Patent Claims:	see list of patent claims

Details for Patent 5,545,727

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	See Plans and Pricing	2013-08-13
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		See Plans and Pricing	2013-08-13
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		See Plans and Pricing	2013-08-13
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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