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Last Updated: March 27, 2023

Patent: 5,538,853

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Summary for Patent: 5,538,853
Title: Bone resorption assay based on a peptide liberated during collagen degradation
Abstract:An antibody raised to type I collagen carboxyterminal cross-linked telopeptide isolated from decalcified human or animal bone, may be used in an assay to determine the concentration of liberated carboxyterminal telopeptide region of the type I collagen molecule in a sample. When the sample is a body fluid such as serum or urine the degradation product measured is resistant to further degradation, since it contains a multivalent intermolecular cross-link, and can thus be found in the body fluid. The assay may be used to assess the degradation of type I collagen, the major organic constituent of bone matrix.
Inventor(s): Risteli; Juha P. (Oulu, FI), Risteli; Leila T. (Oulu, FI)
Assignee: Orion Corporation, Orion Diagnostica (Koivumankkaankuja, FI)
Application Number:08/274,105
Patent Claims:see list of patent claims

Details for Patent 5,538,853

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Smith & Nephew, Inc. SANTYL collagenase Ointment 101995 06/04/1965 See Plans and Pricing 2013-07-23
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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