Genetically engineered or transduced hepatocytes which express genetic material of interest introduced or incorporated into them, as well as methods of producing, transplanting and using the genetically engineered hepatocytes are disclosed. The genetic material of interest can be incorporated through the use of a vector, such as a recombinant retrovirus, which contains the genetic material of interest, or by other means.
Mulligan; Richard C. (Lincoln, MA), Wilson; James M. (Ann Arbor, MI)
Whitehead Institute For Biomedical Research (Cambridge, MA) Howard Hughes Medical Center (Bethesda, MD)
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