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Last Updated: September 26, 2020

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Patent: 5,422,261

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Summary for Patent: 5,422,261
Title: Composition containing collagenase and chymopapain for hydrolyzing connective tissue to isolate cells
Abstract:Proteolytic enzyme compositions and processes for digesting connective tissue are disclosed. The enzyme compositions include collagenase, which is essentially free of toxins and non-collagen specific components, and chymopapain, which is essentially free of toxins. The enzyme compositions are used for dissociating microvessel cells from connective tissue. Recovered microvessel cells are incorporated into artificial vessel grafts. The enzyme compositions preferably contain an aqueous mixture of collagenase having an activity of about 43 nkat/ml to about 51 nkat/ml, and chymopapain having an activity of about 0.22 nkat/ml to about 0.44 nkat/ml.
Inventor(s): Lee; Catherine T. (Laguna Hills, CA), Hornacek; Cynthia (Trabuco cyn, CA), Dinh; Tan T. (Garden Grove, CA)
Assignee: Baxter International Inc. (Deerfield, IL)
Application Number:08/049,015
Patent Claims:see list of patent claims

Details for Patent 5,422,261

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Discure Medical, Llc CHYMODIACTIN chymopapain INJECTABLE;INJECTION 018663 001 1984-07-09   Start Trial Baxter International Inc. (Deerfield, IL) 2039-03-29 DISCN search
Discure Medical, Llc CHYMODIACTIN chymopapain INJECTABLE;INJECTION 018663 002 1984-07-09   Start Trial Baxter International Inc. (Deerfield, IL) 2039-03-29 DISCN search
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Baxter International Inc. (Deerfield, IL) 2039-03-29 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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