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Last Updated: December 8, 2021

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Patent: 5,397,706

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Summary for Patent: 5,397,706
Title: Serum-free basal and culture medium for hematopoietic and leukemia cells
Abstract:A basal serum-free medium and a hematopoietic cell growth and differentiation-promoting serum-free medium based thereon are provided for the maintenance, cultivation, growth and differentiation of erythroid progenitor cells, other hematopoietic progenitor cells, and leukemia cells in which the effects of various growth factor compounds can be quantitatively evaluated. Both media are wholly serum-free and contain no intrinsic growth factor compounds. The hematopoietic growth and differentiation medium consists essentially of the basal serum-free medium to which has been added at least one primarily but not exclusively growth-promoting agent selected from heme or hemin, interleukin-3 and recombinant human stem cell factor (and optimally all of them), and at least one primarily but not exclusively cell differentiation -promoting agent selected from erythropoietin (Epo), insulin-like growth factor (IGF) and a retinoid (and optimally including all of them).
Inventor(s): Correa; Paulo N. (Concord, Ontario, CA), Alexrad; Arthur A. (Willowdale, Ontario, CA)
Application Number:08/103,419
Patent Claims:see list of patent claims

Details for Patent 5,397,706

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Grifols Therapeutics Llc ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5 albumin (human) For Injection 101138 1942-10-21 ⤷  Free Forever Trial 2012-03-14
Recordati Rare Diseases, Inc. PANHEMATIN hemin for injection For Injection 101246 1983-07-20 ⤷  Free Forever Trial 2012-03-14
Baxalta Us Inc. BUMINATE, FLEXBUMIN albumin (human) Injection 101452 1954-03-03 ⤷  Free Forever Trial 2012-03-14
Csl Behring Ag ALBURX albumin (human) Injection 102366 1976-07-23 ⤷  Free Forever Trial 2012-03-14
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Serving leading biopharmaceutical companies globally:

Express Scripts
Boehringer Ingelheim

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