Patent: 5,382,658

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Summary for Patent: 5,382,658

Title:	Stability-enhanced variants of parathyroid hormone
Abstract:	Herein described are variants of parathyroid hormone that retain significant PTH activity and are substantially resistant to trypsin and trypsin-like enzymes. The variants are useful pharmaceutically, to treat bone disorders such as osteoporosis and in other therapeutic applications. Specific embodiments of the invention include [His.sup.25 ]PTH and [His.sup.25 His.sup.26 Leu.sup.27 ]PTH.
Inventor(s):	Kronis; K. Anne (Toronto, CA), Bozzato; Richard P. (Etobicoke, CA)
Assignee:	Allelix Biopharmaceuticals Inc. (Mississauga, CA) Glaxo Canada Inc. (Mississauga, CA)
Application Number:	07/863,014
Patent Claims:	see list of patent claims

Details for Patent 5,382,658

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015	See Plans and Pricing	2039-03-29
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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