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Last Updated: July 2, 2020

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Patent: 5,328,470

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Summary for Patent: 5,328,470
Title: Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
Abstract:A method for the direct treatment towards the specific sites of a disease is disclosed. This method is based on the delivery of proteins by catheterization to discrete blood vessel segments using genetically modified or normal cells or other vector systems. Endothelial cells expressing recombinant therapeutic agent or diagnostic proteins are situated on the walls of the blood vessel or in the tissue perfused by the vessel in a patient. This technique, provides for the transfer of cells or vectors and expression of recombinant genes in vivo and allows the introduction of proteins of therapeutic or diagnostic value for the treatment of diseases.
Inventor(s): Nabel; Elizabeth G. (Ann Arbor, MI), Nabel; Gary J. (Ann Arbor, MI)
Assignee: The Regents of the University of Michigan (Ann Arbor, MI)
Application Number:07/741,244
Patent Claims:see list of patent claims

Details for Patent 5,328,470

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial The Regents of the University of Michigan (Ann Arbor, MI) 2011-07-12 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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