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Last Updated: February 18, 2020

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Patent: 5,322,790

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Summary for Patent: 5,322,790
Title: Islet isolation process
Abstract:A method of producing intact islets of Langerhans in an insulin producing condition uses a mixture of Hank\'s solution and 10% by volume fetal calf serum to ductally distend the human pancreas. The exocrine tissue of the pancreas is digested at about 37.degree. C. by an enzyme preparation of collagenase, trypsin and proteolytic enzyme present in the mixture at a level of about 0.2% by weight. The digestion is monitored at regular intervals during the process. The digested pancreas is comminuted, filtered and intact islets of Langerhans are recovered. The recovered islets retain their insulin producing properties.
Inventor(s): Scharp; David W. (St. Louis, MO), Lacy; Paul E. (Webster Groves, MO), Finke; Edward H. (Jennings, MO), Poteat; Thomas J. (Leslie, MO)
Assignee: McDonnell Douglas Corporation (St. Louis, MO) Washington University (St. Louis, MO)
Application Number:07/364,976
Patent Claims:see list of patent claims

Details for Patent 5,322,790

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial McDonnell Douglas Corporation (St. Louis, MO) Washington University (St. Louis, MO) 2005-02-27 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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