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Last Updated: September 28, 2020

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Patent: 5,320,970

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Summary for Patent: 5,320,970
Title: Detection of collagen degradation in vivo
Abstract:Methods of determining collagen degradation in vivo, by quantitating the concentration of a peptide in a body fluid, the peptide having the following structure: ##STR1## is hydroxylysyl pyridinoline or lysyl pyridinoline, and J is pyroglutamic acid or glutamine and (Leu) are optional leucines, are disclosed. Compositions useful in quantitating collagen peptides to determine the rate of bone resorption are prepared by treating bone with a protease, such as collagenase, and purifying the compositions so as to enrich them with peptides capable of binding to the monoclonal antibody MAb-1H11.
Inventor(s): Eyre; David R. (Mercer Island, WA)
Assignee: Washington Research Foundation (Seattle, WA)
Application Number:07/708,529
Patent Claims:see list of patent claims

Details for Patent 5,320,970

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Washington Research Foundation (Seattle, WA) 2011-06-14 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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