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Last Updated: July 27, 2021

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Patent: 5,308,763

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Summary for Patent: 5,308,763
Title: Method of making primary culture of olfactory neurons
Abstract:A method of producing primary cultures of olfactory neurons which are purified from sustentacular cells and basal cells. The neuronal cells demonstrate responsiveness to physiologic levels of odorants and express Olfactory Marker Protein (OMP). The steps required to obtain the primary cultures are: 1. providing olfactory epithelium of an animal; 2. dissociation of neuronal cells using enzymatic digestion; 3. filtering using a mesh filter having a pore size between 10 and 25 microns to separate cell aggregates; 4. removal of the cell aggregates; and 5. plating the dissociated neuronal cells in a nutrient medium containing D-valine, Nerve Growth Factor (NGF), and other significant ingredients to obtain a culture of olfactory neurons. In addition to OMP the neurons are capable of expressing vimentin, neuron-specific enolase but not expressing glial fibrillary acidic proteins, S-100 protein, keratin, or neurofilament protein.
Inventor(s): Ronnett; Gabriele V. (Baltimore, MD), Hester; Lynda (Towson, MD), Snyder; Solomon H. (Baltimore, MD)
Assignee: The Johns Hopkins University (Baltimore, MD)
Application Number:07/848,687
Patent Claims:see list of patent claims

Details for Patent 5,308,763

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04 ⤷  Try it Free The Johns Hopkins University (Baltimore, MD) 2011-10-01 RX search
Akorn Inc HYDASE hyaluronidase INJECTABLE;INJECTION 021716 001 2005-10-25 ⤷  Try it Free The Johns Hopkins University (Baltimore, MD) 2011-10-01 DISCN search
Amphastar Pharm AMPHADASE hyaluronidase INJECTABLE;INJECTION 021665 001 2005-11-03 ⤷  Try it Free The Johns Hopkins University (Baltimore, MD) 2011-10-01 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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