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Last Updated: September 28, 2020

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Patent: 5,308,620

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Summary for Patent: 5,308,620
Title: Protein nanomatrixes and method of production
Abstract:The present invention is a novel method of producing a unique device of stable porous and membraneless nanomatrixes for carrying medication for in vivo administration. The present invention method produces the device of stable nanomatrixes by mixing a first type of protein which is hemoglobin, a second type of protein which is albumin, and a solution containing an organic solvent which is an alcohol, where the weight ratio of the first and second type of proteins is within the range of approximately 92.+-.5 to 8.+-.5. This results in a turbid suspension of monodispersed nanomatrixes which are typically larger than 1 micron but less than 4 microns in diameter and stable against aggregation and re-solubilization in hypotonic saline for at least 24 hours. An additional solution containing a biologically active substance may be added before or after the solution containing an organic solvent, such that the biologically active substance is entrapped within or bound on the surfaces of the nanomatrixes.
Inventor(s): Yen; Richard C. K. (Glendora, CA)
Assignee: Hemoshpere, Inc. (N/A)
Application Number:07/959,560
Patent Claims:see list of patent claims

Details for Patent 5,308,620

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Grifols Usa, Llc PLASBUMIN albumin (human) SOLUTION 101138 1 1994-09-26   Start Trial Hemoshpere, Inc. (N/A) 2011-05-03 search
Baxalta Us Inc. FLEXBUMIN albumin human INJECTION, SOLUTION 101452 1 2014-07-31   Start Trial Hemoshpere, Inc. (N/A) 2011-05-03 search
Csl Behring Ag ALBURX albumin (human) SOLUTION 102366 1 2009-01-06   Start Trial Hemoshpere, Inc. (N/A) 2011-05-03 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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