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Last Updated: September 28, 2020

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Patent: 5,252,481

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Summary for Patent: 5,252,481
Title: Mutant of bacterium Clostridium histolyticum, a process for the obtaining thereof, and its use in the production of clostripain-free collagenase
Abstract:A mutant of bacterium Clostridium histolyticum, designated Clostridum histolyticum K26 clo 88 of the following characteristics: the lack of a motility system which is a fundamental characteristic of the parenteral strain; and, the inability to biosynthesize the accompanying enzyme clostripain. A process of obtaining the above mutant and its use in a process for the production of clostripain-free collagenase are also provided.
Inventor(s): Holjevac; Milan (Zagreb, YU), Udovicic; Ivan (Zagreb, YU), Cizmek; Sonja (Zagreb, YU), Sojak-Derkos; Vlasta (Zagreb, YU), Gamulin; Stjepan (Zagreb, YU), Delic; Vladimir (Zagreb, YU)
Assignee: Pliva Farmaceutska, Kemijska (YU)
Application Number:07/733,764
Patent Claims:see list of patent claims

Details for Patent 5,252,481

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Pliva Farmaceutska, Kemijska (YU) 2010-10-12 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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