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Last Updated: October 1, 2020

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Patent: 5,227,157

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Summary for Patent: 5,227,157
Title: Delivery of therapeutic agents
Abstract:The present invention relates to a composition of matter for the time-dependent liberation of therapeutic agents. This composition of matter comprises a polymeric slab and a homogeneously dispersed enzyme which degrades the polymeric slab in the presence of moisture. The therapeutic agent is physically entrapped in the polymeric slab by inclusion during polymerization to form the polymeric slab or by mixture of the therapeutic agent with a liquid form of the polymeric slab and conversion of the liquid to a solid form. The therapeutic agent is not chemically bound to the polymer, and thus release of the agent is immediately effected upon the specific moisture-activated enzymatic degradation of the polymer slab. Moisture for enzymatic activation is provided by the biological surface on which the slab is emplaced, such as the dermal surface. The composition comprises a polymer such as poly (DL-lactide) and an enzyme such as proteinase K together with chlorpheniramine maleate as the therapeutic agent.
Inventor(s): McGinity; James W. (Austin, TX), Ashley; Susan L. (Overland Park, KS)
Assignee: Board of Regents, The University of Texas System (Austin, TX)
Application Number:07/388,321
Patent Claims:see list of patent claims

Details for Patent 5,227,157

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Board of Regents, The University of Texas System (Austin, TX) 2010-07-13 RX search
Discure Medical, Llc CHYMODIACTIN chymopapain INJECTABLE;INJECTION 018663 002 1984-07-09   Start Trial Board of Regents, The University of Texas System (Austin, TX) 2010-07-13 DISCN search
Discure Medical, Llc CHYMODIACTIN chymopapain INJECTABLE;INJECTION 018663 001 1984-07-09   Start Trial Board of Regents, The University of Texas System (Austin, TX) 2010-07-13 DISCN search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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