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Last Updated: November 28, 2021

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Patent: 5,225,354

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Summary for Patent: 5,225,354
Title: Monoclonal antibodies specific for human glycoalbumin
Abstract:Monoclonal antibodies specific for the glycosylated lysine residue at position 525 in glycoalbumin and a method for producing such antibodies. The monoclonal antibodies are useful as reagents in immunoassays for the specific determination of glycoalbumin in human blood samples which is indicative of the severity of the diabetic condition. The monoclonal antibodies are secreted by hybridomas obtained by fusing a myeloma cell with a lymphocyte that has been taken from an animal, usually a mouse, immunized with a peptide immunogen and which produces antibody to the lysine 525 residue in glycoalbumin. The synthetic peptide immunogen comprises a peptide residue which includes an .epsilon.-amino glucosylated lysine and an adjacent amino acid sequence in which at least one of the amino acid units is in a position corresponding to the peptide sequence of human albumin adjacent to lysine 525, the glycosylated peptide residue being linked to an immunogenic carrier.
Inventor(s): Knowles; William J. (Madison, CT), Marchesi; Vincent T. (Guilford, CT)
Assignee: Molecular Diagnostics, Inc. (West Haven, CT)
Application Number:07/934,085
Patent Claims:see list of patent claims

Details for Patent 5,225,354

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Grifols Therapeutics Llc ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5 albumin (human) For Injection 101138 1942-10-21 ⤷  Free Forever Trial 2010-07-06
Baxalta Us Inc. BUMINATE, FLEXBUMIN albumin (human) Injection 101452 1954-03-03 ⤷  Free Forever Trial 2010-07-06
Csl Behring Ag ALBURX albumin (human) Injection 102366 1976-07-23 ⤷  Free Forever Trial 2010-07-06
Grifols Biologicals Llc ALBUTEIN albumin (human) Injection 102478 1978-08-15 ⤷  Free Forever Trial 2010-07-06
Instituto Grifols, S.a. HUMAN ALBUMIN GRIFOLS albumin (human) Injection 103352 1995-02-17 ⤷  Free Forever Trial 2010-07-06
Instituto Grifols, S.a. HUMAN ALBUMIN GRIFOLS albumin (human) Injection 103352 2003-06-11 ⤷  Free Forever Trial 2010-07-06
Csl Behring Llc ALBUMINAR, ALBUMINAR-20, ALBUMINAR-25, ALBUMINAR-5 albumin (human) Injection 103955 2000-03-17 ⤷  Free Forever Trial 2010-07-06
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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