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Last Updated: September 22, 2020

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Patent: 5,225,354

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Summary for Patent: 5,225,354
Title: Monoclonal antibodies specific for human glycoalbumin
Abstract:Monoclonal antibodies specific for the glycosylated lysine residue at position 525 in glycoalbumin and a method for producing such antibodies. The monoclonal antibodies are useful as reagents in immunoassays for the specific determination of glycoalbumin in human blood samples which is indicative of the severity of the diabetic condition. The monoclonal antibodies are secreted by hybridomas obtained by fusing a myeloma cell with a lymphocyte that has been taken from an animal, usually a mouse, immunized with a peptide immunogen and which produces antibody to the lysine 525 residue in glycoalbumin. The synthetic peptide immunogen comprises a peptide residue which includes an .epsilon.-amino glucosylated lysine and an adjacent amino acid sequence in which at least one of the amino acid units is in a position corresponding to the peptide sequence of human albumin adjacent to lysine 525, the glycosylated peptide residue being linked to an immunogenic carrier.
Inventor(s): Knowles; William J. (Madison, CT), Marchesi; Vincent T. (Guilford, CT)
Assignee: Molecular Diagnostics, Inc. (West Haven, CT)
Application Number:07/934,085
Patent Claims:see list of patent claims

Details for Patent 5,225,354

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Grifols Usa, Llc PLASBUMIN albumin (human) SOLUTION 101138 1 1994-09-26   Start Trial Molecular Diagnostics, Inc. (West Haven, CT) 2010-07-06 search
Baxalta Us Inc. FLEXBUMIN albumin human INJECTION, SOLUTION 101452 1 2014-07-31   Start Trial Molecular Diagnostics, Inc. (West Haven, CT) 2010-07-06 search
Csl Behring Ag ALBURX albumin (human) SOLUTION 102366 1 2009-01-06   Start Trial Molecular Diagnostics, Inc. (West Haven, CT) 2010-07-06 search
Grifols Usa, Llc ALBUTEIN albumin (human) INJECTION, SOLUTION 102478 1 2019-12-15   Start Trial Molecular Diagnostics, Inc. (West Haven, CT) 2010-07-06 search
Grifols Usa, Llc HUMAN ALBUMIN GRIFOLS albumin (human) SOLUTION 103352 1 2003-06-11   Start Trial Molecular Diagnostics, Inc. (West Haven, CT) 2010-07-06 search
Csl Behring Llc ALBUMINAR-25 albumin (human) SOLUTION 103955 1 2009-01-06   Start Trial Molecular Diagnostics, Inc. (West Haven, CT) 2010-07-06 search
Octapharma Usa Inc ALBUMIN (HUMAN) albumin human SOLUTION 125154 1 2006-10-17   Start Trial Molecular Diagnostics, Inc. (West Haven, CT) 2010-07-06 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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