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Last Updated: March 29, 2023

Patent: 5,225,212

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Summary for Patent: 5,225,212
Title: Microreservoir liposome composition and method
Abstract:A liposome composition for extended release of a therapeutic compound into the bloodstream. The liposomes are composed of vesicle-forming lipids and between 1-20 mole percent of a vesicle-forming lipid derivatized with hydrophilic polymer, have sizes in a selected size range between 0.1 and 0.4 microns, and contain the therapeutic compound in liposome-entrapped form. The dosage form of the composition contains at least about three times the dose of the compound required for intravenous injection in free form. Also disclosed in a method for extending to at least 24 hours the period in which an intravenously administered therapeutic compound is therapeutically active in the bloodstream, and novel liposomes compositions for practicing the method.
Inventor(s): Martin; Francis J. (San Francisco, CA), Woodle; Martin C. (Menlo Park, CA), Redemann; Carl (Walnut Creek, CA), Yau-Young; Annie (Palo Alto, CA), Radhakrishnan; Ramachandran (Fremont, CA)
Assignee: Liposome Technology, Inc. (Menlo Park, CA)
Application Number:07/624,548
Patent Claims:see list of patent claims

Details for Patent 5,225,212

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Microbix Biosystems Inc. KINLYTIC urokinase For Injection 021846 01/16/1978 See Plans and Pricing 2010-07-06
Recordati Rare Diseases, Inc. ELSPAR asparaginase For Injection 101063 01/10/1978 See Plans and Pricing 2010-07-06
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Serving leading biopharmaceutical companies globally:

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