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Last Updated: August 1, 2021

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Patent: 5,225,212

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Summary for Patent: 5,225,212
Title: Microreservoir liposome composition and method
Abstract:A liposome composition for extended release of a therapeutic compound into the bloodstream. The liposomes are composed of vesicle-forming lipids and between 1-20 mole percent of a vesicle-forming lipid derivatized with hydrophilic polymer, have sizes in a selected size range between 0.1 and 0.4 microns, and contain the therapeutic compound in liposome-entrapped form. The dosage form of the composition contains at least about three times the dose of the compound required for intravenous injection in free form. Also disclosed in a method for extending to at least 24 hours the period in which an intravenously administered therapeutic compound is therapeutically active in the bloodstream, and novel liposomes compositions for practicing the method.
Inventor(s): Martin; Francis J. (San Francisco, CA), Woodle; Martin C. (Menlo Park, CA), Redemann; Carl (Walnut Creek, CA), Yau-Young; Annie (Palo Alto, CA), Radhakrishnan; Ramachandran (Fremont, CA)
Assignee: Liposome Technology, Inc. (Menlo Park, CA)
Application Number:07/624,548
Patent Claims:see list of patent claims

Details for Patent 5,225,212

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10 ⤷  Try it Free Liposome Technology, Inc. (Menlo Park, CA) 2010-07-06 RX search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 003 1978-01-16 ⤷  Try it Free Liposome Technology, Inc. (Menlo Park, CA) 2010-07-06 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 002 1978-01-16 ⤷  Try it Free Liposome Technology, Inc. (Menlo Park, CA) 2010-07-06 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 001 1978-01-16 ⤷  Try it Free Liposome Technology, Inc. (Menlo Park, CA) 2010-07-06 DISCN search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 5,225,212

Country Patent Number Estimated Expiration
World Intellectual Property Organization (WIPO) 9105545 ⤷  Try it Free
World Intellectual Property Organization (WIPO) 9105546 ⤷  Try it Free
World Intellectual Property Organization (WIPO) 9319738 ⤷  Try it Free
World Intellectual Property Organization (WIPO) 9407466 ⤷  Try it Free
World Intellectual Property Organization (WIPO) 9422429 ⤷  Try it Free
>Country >Patent Number >Estimated Expiration

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