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Last Updated: September 28, 2020

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Patent: 5,196,320

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Summary for Patent: 5,196,320
Title: Method of producing engineered binding proteins
Abstract:Disclosed are methods of producing fusion proteins including those with dual biological activities. These methods include the provision of a first and second DNA sequence encoding a first and second polypeptide, repectively, the digestion of the first DNA sequence at a restriction site adjacent its 3\' or 5\' terminus, and the ligation of a linker/adapter sequence (l/a) to the restricted end of the first DNA sequence, thereby forming a cassette. The l/a includes, at one end, that portion of the first DNA sequence extending from its terminus nearest the restriction site to the restriction site, and at the other end, one side of a splice site. A eucaryotic host cell is transfected with the cassette and the second DNA sequence having, at one end, one side of a splice site compatible with the side of the splice site on the l/a. The transfected host cell is cultured to express the transfected DNA as a single chain fusion protein.
Inventor(s): Gillies; Stephen D. (Hingham, MA)
Assignee: Abbott Biotech, Inc. (Needham Heights, MA)
Application Number:07/810,522
Patent Claims:see list of patent claims

Details for Patent 5,196,320

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Abbott Biotech, Inc. (Needham Heights, MA) 2010-03-23 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Abbott Biotech, Inc. (Needham Heights, MA) 2010-03-23 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Abbott Biotech, Inc. (Needham Heights, MA) 2010-03-23 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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