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Last Updated: July 11, 2020

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Patent: 5,177,017

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Summary for Patent: 5,177,017
Title: Molecular cloning of the genes responsible for collagenase production from Clostridium histolyticum
Abstract:Genetically engineered E. coli carry vectors containing inserts that code for Clostridium histolyticum collagenase. These inserts code for: (a) a form of collagenase having a molecular weight of about 68,000 daltons in the essential absence of larger forms of collagenase; (b) the 68 kd form of collagenase and a fusion polypeptide consisting of the collagenase protein fused to at least a portion of the .beta.-galactosidase protein of E. coli; or (3) the 68 kd form of collagenase and polypeptides of molecular weight of from above about 68,000 daltons to about 100,000 daltons and having the enzymatic activity of C. histolyticum collagenase as indicated by digestion of .sup.3 H-acetylated collagen and by specific inhibition by 1,10-phenanthroline plus EDTA. The collagenase genes in the transformed E. coli are expressed efficiently in the transformed cells to yield enzymatically active and immunologically cross-reactive collagenase. In particular, the 68 kd form of collagenase is resistant to autocatalytic degradation and is stable to long-term storage. Genetically engineered collagenase, especia The research reported in this application in support of the invention herein received assistance from a grant provided by the Department of Health & Human Services, Public Health Service, National Institute of Diabetes, Digestive and Kidney Disease, Grant No. N43-DK-8-2239.
Inventor(s): Lin; Hun-Chi (Los Angeles, CA), Lei; Shau-Ping (Los Angeles, CA)
Assignee: Trigen, Inc. (Santa Monica, CA)
Application Number:07/498,919
Patent Claims:see list of patent claims

Details for Patent 5,177,017

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Trigen, Inc. (Santa Monica, CA) 2039-03-29 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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