Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
Covalently-linked complexes (CLCs) for targeting a defined population of cells, comprising a targeting protein; a cytotoxic agent; and an enhancing moiety, wherein the enhancing moiety is capable of promoting CLC-target cell interaction are disclosed. Methods for using the claimed CLCs to obtain enhanced in vivo cytotoxicity and enhanced in vivo imaging are also described.
Anderson; David C. (Seattle, WA), Morgan, Jr.; A. Charles (Edmonds, WA), Abrams; Paul G. (Seattle, WA), Fritzberg; Alan R. (Edmonds, WA), Nichols; Everett J. (Seattle, WA)
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