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Generated: July 21, 2019

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Patent: 5,109,120

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Summary for Patent: 5,109,120
Title: Reduction of chemically modified proteins
Abstract:The invention provides chemically modified proteins having a group of the formula: ##STR1## wherein R represents a hydrogen atom or a lower alkyl, m represents an optional positive integer and n represents an integer 1 to 4, the group being bonded to at least one primary amino group of the protein, and a method of producing the same. The chemically modified proteins according to the invention can be produced by reacting a protein with an imidoester of the formula: ##STR2## wherein R, n and m are as defined above, R\' represents a group constituting an imidoester with an adjacent imidoyl group. The chemically modified proteins according to the invention are useful as drugs, among others.
Inventor(s): Ueno; Hayao (Suita, JP), Fujino; Masahiko (Takarazuka, JP)
Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP)
Application Number:07/364,707
Patent Claims:see list of patent claims

Details for Patent 5,109,120

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10 ➤ Sign Up Takeda Chemical Industries, Ltd. (Osaka, JP) ➤ Sign Up RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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Mallinckrodt
Federal Trade Commission
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US Department of Justice
Harvard Business School
Accenture

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