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Last Updated: April 1, 2023

Patent: 5,108,909

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Summary for Patent: 5,108,909
Title: Expression of TPA in mammalian cells
Abstract:Improved expression of tPA in mammalian cells is achieved employing a promoter region functional in a mammalian cell with a DNA sequence coding for tPA, where the sequence is interrupted by at least one intron. Particularly, a viral promoter is employed in conjunction with a hybrid gene having portions of the coding sequence uninterrupted by introns as compared to the wild-type gene and coding sequences interrupted by introns or the wild-type gene or mutants thereof. Plasmid pSV7tPA2I was deposited on Feb. 14, 1985 and given A.T.C.C. Accession No. 40163.
Inventor(s): Haigwood; Nancy L. (Oakland, CA)
Assignee: Chiron Corporation (Emeryville, CA)
Application Number:07/097,271
Patent Claims:see list of patent claims

Details for Patent 5,108,909

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 06/04/1986 ⤷  Sign Up 2009-04-28
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Sign Up 2009-04-28
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b Injection 103132 ⤷  Sign Up 2009-04-28
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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