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Last Updated: September 18, 2020

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Patent: 5,100,788

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Summary for Patent: 5,100,788
Title: Method of producing and isolating IGG-binding protein a fusion peptides and a vector therefor
Abstract:A method of producing and selectively isolating a desired protein or polypeptide or derivative thereof by constructing a recombinant vector comprising a DNA sequence coding for said desired protein or polypeptide operatively linked to a DNA sequence coding for protein A or an active polypeptide fragment thereof or any other macromolecule capable of binding to the constant regions of immunoglobulins, such that said DNA sequences together code for an IgG-binding fusion product between said desired protein or polypeptide and said protein A, active polypeptide fragment thereof or macromolecule; transforming a compatible host with said recombinant vector such that the combined DNA sequences coding for said fusion protein or polypeptide can be expressed by the host, and culturing the transformed host in a suitable growth medium to produce said fusion protein or polypeptide; selectively isolating said fusion protein or polypeptide by adsorption to an IgG-supporting carrier material; and optionally desorbing said fusion protein or polypeptide from said IgG-supporting carrier, said fusion protein or polypeptide coded for by said combined DNA-sequence optionally comprising a unique cleavage site between said protein A part and said desired protein or polypeptide part, said desired protein or polypeptide part then being cleaved off from the rest of the fusion protein or polpeptide either while the latter is adsorbed to the IgG-supporting carrier or after desorption thereof from the carrier. Also a hybrid vector for use herein, a method and an expression vector for its preparation and a host organism transformed by said hybrid vector are disclosed.
Inventor(s): Lofdahl; Sven (Uppsala, SE), Uhlen; Mathias (Uppsala, SE), Lindberg; Martin (Uppsala, SE), Sjoquist; John (Uppsala, SE)
Assignee: Pharmacia LKB Biotechnology AB (Uppsala, SE)
Application Number:07/196,846
Patent Claims:see list of patent claims

Details for Patent 5,100,788

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial Pharmacia LKB Biotechnology AB (Uppsala, SE) 2009-03-31 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial Pharmacia LKB Biotechnology AB (Uppsala, SE) 2009-03-31 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial Pharmacia LKB Biotechnology AB (Uppsala, SE) 2009-03-31 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial Pharmacia LKB Biotechnology AB (Uppsala, SE) 2009-03-31 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

Moodys
Harvard Business School
Baxter
McKesson
Johnson and Johnson
Medtronic

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