Patent: 5,093,246

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Summary for Patent: 5,093,246

Title:	RNA ribozyme polymerases, dephosphorylases, restriction endoribo-nucleases and methods
Abstract:	RNA enzymes or ribozymes can act as endoribonucleases, catalyzing the cleavage of RNA molecules with a sequence specificity of cleavage greater than that of known ribonucleases and approaching that of the DNA restriction endonucleases, thus serving as RNA sequence specific endoribonucleases. An example is a shortened form of the self-splicing ribonsomal RNA intervening sequence of Tetrahymena (L-19 IVS RNA). Site-specific mutagenesis of the enzyme active site of the L-19 IVS RNA alters the substrate sequence specificity in a predictable manner, allowing a set of sequence-specific endoribonucleases to be synthesized. Varying conditions allow the ribozyme to act as a polymerase (nucleotidyltransferase), a dephosphorylase (acid phosphatase or phosphotransferase) or a sequence-specific endoribonuclease.
Inventor(s):	Cech; Thomas R. (Boulder, CO), Zaug; Arthur J. (Louisville, CO), Been; Michael D. (Boulder, CO)
Assignee:	University Patents, Inc. (Westport, CT)
Application Number:	07/562,672
Patent Claims:	see list of patent claims

Details for Patent 5,093,246

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	See Plans and Pricing	2009-03-03
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		See Plans and Pricing	2009-03-03
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		See Plans and Pricing	2009-03-03
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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