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Last Updated: December 2, 2021

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Patent: 5,061,786

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Summary for Patent: 5,061,786
Title: Biologically active polypeptides based on transforming growth factor-.beta.
Abstract:A polypeptide is provided that excludes (a) a full-length mature TGF-.beta. molecule or precursor TGF-.beta. molecule or deletion variants of mature or precursor TGF-.beta. molecules in which from about 1 to 10 amino acid residues have been deleted, (b) a polypeptide of the sequence: Cys-Val-Arg-Gln-Leu-Tyr-Ile-Asp-Phe-Arg-Lys-Asp-Leu-Gly-Trp-Lys, and (c) a polypeptide of the sequence: Arg Asn-Leu-Glu-Glu-Asn-Cys-Cys-Val-Arg-Pro-Leu-Tyr-Ile-Asp-Phe-Arg-Gln-Asp-Le u, said polypeptide comprising an amino acid sequence that is based on conserved sequences in the family of TGF-.beta. molecules. Such polypeptides are particularly useful therapeutically as immunosuppressive agents when coupled to carrier proteins or crosslinked to form polymers.
Inventor(s): Burnier; John P. (Pacifica, CA), Cianciolo; George J. (San Carlos, CA)
Assignee: Genentech, Inc. (South San Francisco, CA)
Application Number:07/356,964
Patent Claims:see list of patent claims

Details for Patent 5,061,786

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Grifols Therapeutics Llc ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5 albumin (human) For Injection 101138 1942-10-21 ⤷  Free Forever Trial 2040-01-28
Baxalta Us Inc. BUMINATE, FLEXBUMIN albumin (human) Injection 101452 1954-03-03 ⤷  Free Forever Trial 2040-01-28
Csl Behring Ag ALBURX albumin (human) Injection 102366 1976-07-23 ⤷  Free Forever Trial 2040-01-28
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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