Methods and compositions are provided for recombinant DNA production of Factor VIIIC and truncated derivatives thereof. Based on amino acid sequences, probes are developed for isolating messenger RNA, cDNA and/or chromosomal DNA encoding for Factor VIIIC. The Factor VIIIC gene in its entirety, a fragment thereof, or a cDNA is then used for expression of Factor VIIIC in a host. The bacteriophage .lambda.FVIII23D containing the 14.43kb EcoRI fragment was deposited at the A.T.C.C. on Jan. 4, 1984 and given Accession No. 40094. Also, the vector pSVF8-200 was deposited at the A.T.C.C. on July 17, 1985 and given Accession No. 40190.
Kuo; George (San Francisco, CA), Masiarz; Frank (San Francisco, CA), Truett; Martha (Oakland, CA), Valenzuela; Pablo (San Francisco, CA), Rasmussen; Mirella E. (Copenhagen, DK), Favaloro; Jennifer M. (Victoria, AU), Caput; Daniel (San Francisco, CA), Burke; Rae L. (San Francisco, CA), Pachl; Carol (Oakland, CA)
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