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Last Updated: December 5, 2019

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Patent: 5,045,455

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Summary for Patent: 5,045,455
Title: Factor VIII:C cDNA cloning and expression
Abstract:Methods and compositions are provided for recombinant DNA production of Factor VIIIC and truncated derivatives thereof. Based on amino acid sequences, probes are developed for isolating messenger RNA, cDNA and/or chromosomal DNA encoding for Factor VIIIC. The Factor VIIIC gene in its entirety, a fragment thereof, or a cDNA is then used for expression of Factor VIIIC in a host. The bacteriophage .lambda.FVIII23D containing the 14.43kb EcoRI fragment was deposited at the A.T.C.C. on Jan. 4, 1984 and given Accession No. 40094. Also, the vector pSVF8-200 was deposited at the A.T.C.C. on July 17, 1985 and given Accession No. 40190.
Inventor(s): Kuo; George (San Francisco, CA), Masiarz; Frank (San Francisco, CA), Truett; Martha (Oakland, CA), Valenzuela; Pablo (San Francisco, CA), Rasmussen; Mirella E. (Copenhagen, DK), Favaloro; Jennifer M. (Victoria, AU), Caput; Daniel (San Francisco, CA), Burke; Rae L. (San Francisco, CA), Pachl; Carol (Oakland, CA)
Assignee: Chiron Corporation (Emeryville, CA)
Application Number:07/538,691
Patent Claims:see list of patent claims

Details for Patent 5,045,455

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Chiron Corporation (Emeryville, CA) 2008-09-03 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Chiron Corporation (Emeryville, CA) 2008-09-03 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Chiron Corporation (Emeryville, CA) 2008-09-03 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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