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Last Updated: September 27, 2020

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Patent: 5,039,705

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Summary for Patent: 5,039,705
Title: Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
Abstract:This invention concerns anti-hypertensive compositions and a method of lowering blood pressure in mammals. The active component of the compositions is a compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are independently chosen from straight chain and branched chain C.sub.1 -C.sub.12 alkyl groups and benzyl, with the proviso that no branch occur on the alpha carbon atom of the alkyl groups; or R.sub.1 and R.sub.2 together with the nitrogen atom they are bonded to form a pyrrolidino, piperidino, piperazino or morpholino group, M.sup.+ is a pharmaceutically acceptable cation, wherein X is the valence of the cation.
Inventor(s): Keefer; Larry K. (Bethesda, MD), Wink; David A. (Frederick, MD), Dunams; Tambra M. (Frederick, MD), Hrabie; Joseph A. (Frederick, MD)
Assignee: The United States of America as represented by the Department of Health (Washington, DC)
Application Number:07/409,552
Patent Claims:see list of patent claims

Details for Patent 5,039,705

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 125123 001 2006-05-25   Start Trial The United States of America as represented by the Department of Health (Washington, DC) 2039-09-23 search
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 125123 1 2006-05-25   Start Trial The United States of America as represented by the Department of Health (Washington, DC) 2039-09-23 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Mallinckrodt
Merck
Express Scripts
McKesson

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