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Last Updated: December 11, 2019

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Patent: 5,034,428

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Summary for Patent: 5,034,428
Title: Immobilized biomolecules and method of making same
Abstract:A method of biomolecule immobilization is described in which the biomolecule itself or, alternatively, a monomer-conjugated biomolecule, is grafted with free monomer onto a hydrophilic, solid-phase, polymeric substrate which has been pre-irradiated with ionizing radiation. The pre-irradiation step is carried out, preferably at C. in air, while the grafting step is carried out at C. in a substantially oxygen-free atmosphere. The technique is applicable to immobilization of a wide variety of biomolecules, such as enzymes, catalysts, hormones, lectins, drugs, vitamins, antibodies, antigens, nucleic acids, DNA and RNA segments, pesticides, dyes and fertilizers. The products may be used for therapeutic or diagnostic applications or bioseparations.
Inventor(s): Hoffman; Allan S. (Seattle, WA), Dong; Liang C. (Seattle, WA)
Assignee: Board of Regents of the University of Washington (Seattle, WA)
Application Number:07/348,049
Patent Claims:see list of patent claims

Details for Patent 5,034,428

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial Board of Regents of the University of Washington (Seattle, WA) 2006-06-19 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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