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Last Updated: June 4, 2023

Patent: 5,001,048

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Summary for Patent: 5,001,048
Title: Electrical biosensor containing a biological receptor immobilized and stabilized in a protein film
Abstract:An electrical biosensor for analyte determination is prepared by polymerization of a mixture of a biological receptor capable of binding an analyte in a sample, a protein and a polymerizing agent such as glutaraldehyde to form a polymeric film on a transducer. The mixture preferably contains a stabilizer selected from lipids, detergents and antioxidents. The receptor may be an acetylcholine receptor and the analyte, acetylcholine. A preferred stabilizer is a combination of phosphatidyl choline and octyphenoxypolyethoxyethanol. In carrying out a determination, analyte in a sample binds to the receptor causing a change in an electrical characteristic of the film which is indicative of the presence of the analyte. The biosensor may contain a second polymeric film that is free of the receptor and which serves as a control.
Inventor(s): Taylor; Richard F. (Boxford), Marenchic; Ingrid G. (Walpole), Cook; Edward J. (South Hamilton, MA)
Assignee: Aurthur D. Little, Inc. (Cambridge, MA)
Application Number:07/058,389
Patent Claims:see list of patent claims

Details for Patent 5,001,048

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Grifols Therapeutics Llc ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5 albumin (human) For Injection 101138 10/21/1942 ⤷  Try a Trial 2040-01-28
Baxalta Us Inc. BUMINATE, FLEXBUMIN albumin (human) Injection 101452 03/03/1954 ⤷  Try a Trial 2040-01-28
Csl Behring Ag ALBURX albumin (human) Injection 102366 07/23/1976 ⤷  Try a Trial 2040-01-28
Grifols Biologicals Llc ALBUTEIN albumin (human) Injection 102478 08/15/1978 ⤷  Try a Trial 2040-01-28
Instituto Grifols, S.a. HUMAN ALBUMIN GRIFOLS albumin (human) Injection 103352 02/17/1995 ⤷  Try a Trial 2040-01-28
Instituto Grifols, S.a. HUMAN ALBUMIN GRIFOLS albumin (human) Injection 103352 06/11/2003 ⤷  Try a Trial 2040-01-28
Csl Behring Llc ALBUMINAR, ALBUMINAR-20, ALBUMINAR-25, ALBUMINAR-5 albumin (human) Injection 103955 03/17/2000 ⤷  Try a Trial 2040-01-28
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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