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Last Updated: September 20, 2020

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Patent: 4,985,360

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Summary for Patent: 4,985,360
Title: Novel bilirubin oxidase which has a substrate specifity to bilirubin, but not to biliverdin, catechol and hemin
Abstract:A novel bilirubin oxidase is provided having a substrate specificity for bilirubin but not to, at least, biliverdin, catechol and hemin and which catalyzes the enzyme reaction between two moles of bilirubin and one mole of oxygen to yield two moles of biliverdin and two moles of water. A process is also provided for the production of said novel bilirubin oxidase, which comprises cultivating a bilirubin oxidase-producing fungus of the genus Penicillium in a culture medium and collecting the bilirubin oxidase from the culture mixture. A method of determining the content of bilirubin in a sample to be analyzed is further provided which comprises contacting the sample with the bilirubin oxidase to convert bilirubin in the sample into biliverdin and determining the amount of biliverdin formed or the amount of oxygen consumed therefor, as well as a method for removing bilirubin contained in a sample to be analyzed, which comprises contacting the sample with said novel bilirubin oxidase.
Inventor(s): Takahashi; Mamoru (Shizuoka, JP), Imamura; Shigeyuki (Shizuoka, JP), Takada; Masaki (Shizuoka, JP)
Assignee: Toyo Jozo Kabushiki Kaisha (Shizuoka, JP)
Application Number:07/204,868
Patent Claims:see list of patent claims

Details for Patent 4,985,360

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Recordati Rare Diseases, Inc. PANHEMATIN hemin POWDER, FOR SOLUTION 101246 1 1983-07-20   Start Trial Toyo Jozo Kabushiki Kaisha (Shizuoka, JP) 2008-01-15 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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