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Last Updated: October 29, 2020

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Patent: 4,970,156

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Summary for Patent: 4,970,156
Title: Immobilization of active protein by cross-linking to inactive protein
Abstract:A solution of an active protein substance and an inactive protein substance is reacted with a cross-linking agent, optionally in the presence of an inert carrier, under cross-linking conditions to produce articles comprising both active and inactive protein substances. The active protein substance comprises up to about 20 percent, e.g. from 1 to 20 percent by weight, based on the final weight of the total protein substance, whereas the cross-linking agent comprises from 0.5 to 8 percent by weight, based on the weight of the total treated mixture. The obtained articles are in the form of a solution or a suspension in aqueous medium, in the form of a film, in the form of a membrane, in the form of a fabric, in the form of a porous material, or in the form of a mass, such as granules, pills or tablets.
Inventor(s): Avrameas; Statis (La Celle Saint Cloud, FR), Broun; Georges (Rouen, FR), Selegny; Eric (Rouen, FR), Thomas; Daniel (Rouen, FR)
Assignee: Agence Nationale de Valorisation de la Recherche (FR)
Application Number:06/775,956
Patent Claims:see list of patent claims

Details for Patent 4,970,156

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Agence Nationale de Valorisation de la Recherche (FR) 2007-11-13 RX search
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial Agence Nationale de Valorisation de la Recherche (FR) 2007-11-13 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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