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Last Updated: July 26, 2021

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Patent: 4,959,314

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Summary for Patent: 4,959,314
Title: Cysteine-depleted muteins of biologically active proteins
Abstract:Muteins of biologically active proteins such as IFN-.beta. and IL-2 in which cysteine residues that are not essential to biological activity have been deleted or replaced with other amino acids to eliminate sites for intermolecular crosslinking or incorrect intramolecular disulfide bridge formation. These muteins are made via bacterial expression of mutant genes that encode the muteins that have been synthesized from the genes for the parent proteins by oligonucleotide-directed mutagenesis.
Inventor(s): Mark; David F. (Danville, CA), Lin; Leo S. (Fremont, CA), Yu Lu; Shi-da (Oakland, CA), Wang; Alice M. (Walnut Creek, CA)
Assignee: Cetus Corporation (Emeryville, CA)
Application Number:06/698,939
Patent Claims:see list of patent claims

Details for Patent 4,959,314

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Bayer Healthcare Pharms BETASERON interferon beta-1b VIAL; SUBCUTANEOUS 103471 001 1993-07-23 ⤷  Free Forever Trial Cetus Corporation (Emeryville, CA) 2002-10-19 RX Orphan company
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 4,959,314

Country Patent Number Estimated Expiration
South Africa 8507906 ⤷  Free Forever Trial
World Intellectual Property Organization (WIPO) 8602381 ⤷  Free Forever Trial
World Intellectual Property Organization (WIPO) 8604606 ⤷  Free Forever Trial
United States of America 4677063 ⤷  Free Forever Trial
United States of America 4677064 ⤷  Free Forever Trial
>Country >Patent Number >Estimated Expiration

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