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Last Updated: August 11, 2020

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Patent: 4,937,182

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Summary for Patent: 4,937,182
Title: Method for predicting chemosensitivity of anti-cancer drugs
Abstract:An assay for determining the sensitivity of an individual patient tumor to particular chemotherapeutic drugs relies on growth of the neoplastic tumor cells in a mass culture. The mass culture medium provides metabolites essential for the growth of the cells, even in the presence of the particular drug being tested, which is usually an anti-metabolic drug. The mass culture of cells is exposed to a labelled analog of the drug, and the uptake of the labelled drug analog determined. By comparing the amount of the drug uptake by the neoplastic cells with that of the corresponding normal cells, drug sensitivity may be assessed. The method is particularly useful with fluorescently-labelled drugs where the uptake may be assessed by use of a fluorescence activated cell sorter.
Inventor(s): Hancock; Miriam E. C. (Oakland, CA), Smith; Helene S. (Oakland, CA), Hackett; Adeline J. (Orinda, CA)
Assignee: Peralta Cancer Research Institute (San Leandro, CA)
Application Number:07/307,552
Patent Claims:see list of patent claims

Details for Patent 4,937,182

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Peralta Cancer Research Institute (San Leandro, CA) 2007-06-26 RX search
Akorn Inc HYDASE hyaluronidase INJECTABLE;INJECTION 021716 001 2005-10-25   Start Trial Peralta Cancer Research Institute (San Leandro, CA) 2007-06-26 DISCN search
Amphastar Pharm AMPHADASE hyaluronidase INJECTABLE;INJECTION 021665 001 2005-11-03   Start Trial Peralta Cancer Research Institute (San Leandro, CA) 2007-06-26 RX search
Bausch And Lomb VITRASE hyaluronidase INJECTABLE;INJECTION 021640 002 2004-12-21   Start Trial Peralta Cancer Research Institute (San Leandro, CA) 2007-06-26 RX search
Bausch And Lomb VITRASE hyaluronidase INJECTABLE;INJECTION 021640 001 2004-12-21   Start Trial Peralta Cancer Research Institute (San Leandro, CA) 2007-06-26 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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