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Last Updated: August 1, 2021

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Patent: 4,889,803

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Summary for Patent: 4,889,803
Title: Production of interferon gamma
Abstract:Interferon .gamma. is produced in highly purified form (activity exceeding 10.sup.8 units/ml-day) by CHO cells cotransformed by a first plasmid bearing the genomic human interferon gene under the control of the SV40 early promoter, and a second plasmid bearing a DHFR gene under similar control. Methotrexate selection yielded a clone which was a particularly efficient producer. Production of interferon .gamma. may also be facilitated by a Harvey sarcoma virus enhancer sequence.
Inventor(s): Revel; Michel (Rehovot, IL), Rubinstein; Menachem (Givat-Shmuel, IL), Mory; Yvez (Rehovot, IL)
Assignee: Yeda Research & Development Co., Ltd. (Rehovot, IL)
Application Number:06/727,673
Patent Claims:see list of patent claims

Details for Patent 4,889,803

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04 ⤷  Try it Free Yeda Research & Development Co., Ltd. (Rehovot, IL) 2006-12-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04 ⤷  Try it Free Yeda Research & Development Co., Ltd. (Rehovot, IL) 2006-12-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04 ⤷  Try it Free Yeda Research & Development Co., Ltd. (Rehovot, IL) 2006-12-26 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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