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Last Updated: October 26, 2020

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Patent: 4,885,207

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Summary for Patent: 4,885,207
Title: Biocompatible protein or ligand immobilization system
Abstract:A support matrix generally useful for the immobilization of biologically active proteins is made by coating with a polymeric alcohol a core support of titania or a carbonaceous pyropolymer deposited on a high surface area refractory inorganic oxide, cross-linking the alcohol, and converting a portion of the hydroxyl moieties to sulfonate esters. Such supports covalently bind enzymes and antibodies via a strong carbon-nitrogen single bond to give, for example, an immobilized antibody system extremely resistant to leaching of the antibody, the cross-linked alcohol, or of metals from the core support.
Inventor(s): Johnson; Susan S. (E. Forest Lake, IL), Goodman; James R. (Chicago, IL)
Assignee: UOP (Des Plaines, IL)
Application Number:07/073,251
Patent Claims:see list of patent claims

Details for Patent 4,885,207

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial UOP (Des Plaines, IL) 2039-03-29 RX search
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial UOP (Des Plaines, IL) 2039-03-29 RX search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 003 1978-01-16   Start Trial UOP (Des Plaines, IL) 2039-03-29 DISCN search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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