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Last Updated: July 5, 2020

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Patent: 4,849,353

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Summary for Patent: 4,849,353
Title: Immunocapture of enzyme inhibitor, enzyme complexes and uses thereof
Abstract:This invention relates to methods for detecting, identifying and quantifying enzymes, for example, human proteolytic enzymes. The method broadly comprises forming an immobilized or insoluble complex comprising enzyme, enzyme inhibitor and enzyme inhibitor-antibody reactive site and then detecting and identifying, preferably quantitatively, one or more enzymes bound to the complex, or one or more inhibitor antibodies bound to the complex to indirectly detect one or more bound enzyme. In a preferred embodiment, a matrix, e.g. solid or semisolid surface or permeable matrix, has affixed thereto enzyme inhibitor-antibody or an immonologically active (inhibitor binding) fragment of such an antibody. This insoluble enzyme inhibitor interacting matrix is then contacted with The invention described herein was at least in part made in the course of work under a grant or award from the Department of Health, Education and Welfare (Grant No. HL 18828, Department of Health & Human Services).
Inventor(s): Harpel; Peter C. (New York, NY)
Assignee: Cornell Research Foundation, Inc. (Ithaca, NY)
Application Number:06/712,473
Patent Claims:see list of patent claims

Details for Patent 4,849,353

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Cornell Research Foundation, Inc. (Ithaca, NY) 2039-03-29 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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