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Last Updated: September 22, 2020

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Patent: 4,810,631

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Summary for Patent: 4,810,631
Title: Signal enhancement in immunoassay by modulation of chemical catalysis
Abstract:A method for immunoassay for a ligand suspected to be present in a fluid includes use of an enzyme, a metal ion catalyst for an indicator reaction and a blocked modulator for the catalyst. Ligand present in the fluid binds to an antiligand. The resulting bound fraction activates the enzyme to unblock the modulator. The free modulator activates or inhibits the catalyst thereby modulating the rate of an indicator reaction between a substrate and a redox reagent. The presence of absence of the ligand in the fluid is indicated by a signal, such as a color change or a rate of color change, consequent to the indicator reaction. The invention includes a kit of materials useful for performing the method of the invention.
Inventor(s): Perlman; Michael E. (Durham, NC), Evans; Susan A. (Miami, FL)
Assignee: Becton, Dickinson and Company (Franklin Lakes, NJ)
Application Number:06/861,818
Patent Claims:see list of patent claims

Details for Patent 4,810,631

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Recordati Rare Diseases, Inc. PANHEMATIN hemin POWDER, FOR SOLUTION 101246 1 1983-07-20   Start Trial Becton, Dickinson and Company (Franklin Lakes, NJ) 2040-01-28 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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