Nuclear binding assay for steroid receptor functionality in cancerous cells
A method for rapidly determining the presence of functional cellular steroid receptors by assaying a tissue sample for nuclear steroid or antisteroid binding is disclosed which comprises treating the tissue with collagenase, incubating the isolated cells with a labelled steroid or a labelled antisteroid capable of complexing said receptors and measuring the bound nuclear radioactivity and the DNA of the isolated cellular nuclei.
Spelsberg; Thomas C. (Rochester, MN)
Mayo Foundation for Medical Education and Research (Rochester, MN)
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