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Last Updated: July 28, 2021

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Patent: 4,798,800

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Summary for Patent: 4,798,800
Title: Process for isolating human globular domain NC1 of basal membrane collagen from human tissue
Abstract:The present invention provides human characterized by a molecular weight of about 170,000 Dalton, a hexameric structure with monomeric subunits with a molecular weight of about 28,000 Dalton and a carbohydrate content of about 2%. The present invention provides a process for obtaining and purifying globular domain NC1 of basal membrane collagen, wherein human or animal tissue is subjected to a first limiting treatment with bacterial collagenase, the degradation products obtained are separated from non-collagen proteins by chromatography on a weakly basic anion exchanger, the collagen degradation products are then subjected to a second collagenase digestion at an elevated temperature and the globular domain NC1 is purified by molecular sieve fractionation. Furthermore, the present invention is concerned with the use of this for the determination in body fluids in the case of the use of their antibodies, as well as far the detection of antibodies directed thereagainst in body fluids.
Inventor(s): Timpl; Rupert (Gauting, DE), Brocks; Dietrich (Hunfelden, DE)
Assignee: Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften e.V. (Gottingen, DE)
Application Number:06/664,538
Patent Claims:see list of patent claims

Details for Patent 4,798,800

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04 ⤷  Free Forever Trial Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften e.V. (Gottingen, DE) 2006-01-17 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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