CDNA clones coding for polypeptides exhibiting IGE binding factor activity
Plasmid vectors are provided that carry complementary DNA (cDNA) clones coding for polypeptides exhibiting mammalian IgE binding factor activity. One of these clones contains an open reading frame consisting of 556 codons. The cDNA is derived from messenger RNA isolated from a rat/mouse T-cell hybridoma line. The cDNA was cloned by incorporation into a pcD plasmid vector. The plasmid vector also contains DNA segments from the SV40 virus, permitting expression of the cDNA to form a polypeptide having IgE potentiating activity after transfection into a mammalian host cell, such as monkey Cos7 cells.
Martens; Christine L. (Menlo Park, CA), Moore; Kevin W. (San Bruno, CA), Ishizaka; Kimishige (Towson, MD), Huff; Thomas F. (Baltimore, MD)
DNAX Research Institute of Molecular and Cellular Biology, Inc. (Palo Alto, CA) The Johns Hopkins University (Baltimore, MD)
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