Compositions and methods useful for the prevention or treatment of a human or animal disorder or for the regulation of a human or animal physiological condition are provided. The compositions used comprise, in admixture, a biologically-effective amount of a drug specific for the disorder or condition and a biocompatible, water-soluble, amphiphilic steroid, other than a natural bile salt, which is capable of increasing drug permeability of the human or animal body surface across which the drug is to be administered, in an amount effective to increase the permeability of the surface to the drug.
Carey; Martin C. (Wellesley, MA), Moses; Alan C. (Waban, MA), Flier; Jeffrey S. (West Newton, MA)
Beth Israel Hospital Assn. (Boston, MA) The Brigham and Womens Hospital, Inc. (Boston, MA)
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