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Last Updated: September 26, 2022

Patent: 4,743,552


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Summary for Patent: 4,743,552
Title: Method for growth in tissue culture of normal colonic epithelial cells and method for determination of preneoplastic color cells
Abstract:The invention concerns a method for the routine primary culture of human colonic epithelial cells within a monolayer. 12-0-tetradecanoylphorbol-13-acetate (TPA) enhanced DNA synthesis an average of 8 fold when assayed by [.sup.3 h]dThd labeling indices (L.I.) in colonic epithelial cells from familial polyposis patients and in tubular adenomas. No such stimulation by TPA was seen in cells from high-risk patients without familial polyposis, or in cells from low-risk subjects.
Inventor(s): Friedman; Eileen A. (New York, NY), Lipkin; Martin (New York, NY)
Assignee: Sloan-Kettering Institute for Cancer Research (New York, NY)
Application Number:06/655,090
Patent Claims:see list of patent claims

Details for Patent 4,743,552

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Bausch & Lomb Incorporated VITRASE hyaluronidase Injection 021640 05/05/2004 See Plans and Pricing 2039-03-29
Bausch & Lomb Incorporated VITRASE hyaluronidase Injection 021640 12/02/2004 See Plans and Pricing 2039-03-29
Amphastar Pharmaceuticals, Inc. AMPHADASE hyaluronidase Injection 021665 10/26/2004 See Plans and Pricing 2039-03-29
Akorn, Inc. HYDASE hyaluronidase Injection 021716 10/25/2005 See Plans and Pricing 2039-03-29
Smith & Nephew, Inc. SANTYL collagenase Ointment 101995 06/04/1965 See Plans and Pricing 2039-03-29
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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