Patent: 4,742,158
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Summary for Patent: 4,742,158
| Title: | Purification of hepatitis pre-S antigens by polymerized serum albumin affinity binding |
| Abstract: | Recombinant pre-S-HBsAg is purified by a rapid and efficient two step chromatographic process. Yeast cells expressing recobinant pre-S-HBsAg are disrupted, the cell contents are clarified and separated by polymerized human serum albumin affinity chromatography. The pre-S-HBsAg is further purified by hydrophobic interaction chromatography using butyl agarose. This process results in pre-S-HBsAg that is greater than 90% pure. |
| Inventor(s): | Lehman; E. Dale (Lansdale, PA), Schaefer; Ted F. (Collegeville, PA), McAleer; William J. (Ambler, PA) |
| Assignee: | Merck & Co., Inc. (Rahway, NJ) |
| Application Number: | 07/045,792 |
| Patent Claims: | see list of patent claims |
Details for Patent 4,742,158
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Grifols Therapeutics Llc | ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5 | albumin (human) | For Injection | 101138 | 10/21/1942 | ⤷ Try a Trial | 2006-04-25 |
| Baxalta Us Inc. | BUMINATE, FLEXBUMIN | albumin (human) | Injection | 101452 | 03/03/1954 | ⤷ Try a Trial | 2006-04-25 |
| Csl Behring Ag | ALBURX | albumin (human) | Injection | 102366 | 07/23/1976 | ⤷ Try a Trial | 2006-04-25 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
