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Last Updated: September 24, 2023

Patent: 4,742,158

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Summary for Patent: 4,742,158
Title: Purification of hepatitis pre-S antigens by polymerized serum albumin affinity binding
Abstract:Recombinant pre-S-HBsAg is purified by a rapid and efficient two step chromatographic process. Yeast cells expressing recobinant pre-S-HBsAg are disrupted, the cell contents are clarified and separated by polymerized human serum albumin affinity chromatography. The pre-S-HBsAg is further purified by hydrophobic interaction chromatography using butyl agarose. This process results in pre-S-HBsAg that is greater than 90% pure.
Inventor(s): Lehman; E. Dale (Lansdale, PA), Schaefer; Ted F. (Collegeville, PA), McAleer; William J. (Ambler, PA)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Application Number:07/045,792
Patent Claims:see list of patent claims

Details for Patent 4,742,158

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Grifols Therapeutics Llc ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5 albumin (human) For Injection 101138 10/21/1942 ⤷  Try a Trial 2006-04-25
Baxalta Us Inc. BUMINATE, FLEXBUMIN albumin (human) Injection 101452 03/03/1954 ⤷  Try a Trial 2006-04-25
Csl Behring Ag ALBURX albumin (human) Injection 102366 07/23/1976 ⤷  Try a Trial 2006-04-25
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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