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Last Updated: October 6, 2022

Patent: 4,737,462


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Summary for Patent: 4,737,462
Title: Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-.beta.
Abstract:A modified IFN-.beta. is provided wherein the cysteine residue at position 17 is deleted and serine is substituted therefor. DNA sequences coding for the modified protein, nucleotide primers used for the mutagenesis, appropriate cloning vectors, host organisms transformed with the vectors, methods for the production and use of the modified IFN-.beta. (IFN-.beta..sub.ser17) are also provided. The specific activity of IFN-.beta..sub.ser17 is found to be substantially the same as that of native IFN-.beta..
Inventor(s): Mark; David F. (Hercules, CA), Lin; Leo S. (Fremont, CA), Yu Lu; Shi-Da (Oakland, CA)
Assignee: Cetus Corporation (Emeryville, CA)
Application Number:06/753,717
Patent Claims:see list of patent claims

Details for Patent 4,737,462

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Bayer Healthcare Pharmaceuticals Inc. BETASERON interferon beta-1b For Injection 103471 07/23/1993 See Plans and Pricing 2005-04-12
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

International Patent Family for US Patent 4,737,462

Country Patent Number Estimated Expiration
South Africa 837789 See Plans and Pricing
United States of America RE33653 See Plans and Pricing
United States of America 4853332 See Plans and Pricing
United States of America 4588585 See Plans and Pricing
United States of America 4518584 See Plans and Pricing
Portugal 77512 See Plans and Pricing
Philippines 23702 See Plans and Pricing
>Country >Patent Number >Estimated Expiration

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