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Last Updated: July 24, 2021

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Patent: 4,737,462

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Summary for Patent: 4,737,462
Title: Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-.beta.
Abstract:A modified IFN-.beta. is provided wherein the cysteine residue at position 17 is deleted and serine is substituted therefor. DNA sequences coding for the modified protein, nucleotide primers used for the mutagenesis, appropriate cloning vectors, host organisms transformed with the vectors, methods for the production and use of the modified IFN-.beta. (IFN-.beta..sub.ser17) are also provided. The specific activity of IFN-.beta..sub.ser17 is found to be substantially the same as that of native IFN-.beta..
Inventor(s): Mark; David F. (Hercules, CA), Lin; Leo S. (Fremont, CA), Yu Lu; Shi-Da (Oakland, CA)
Assignee: Cetus Corporation (Emeryville, CA)
Application Number:06/753,717
Patent Claims:see list of patent claims

Details for Patent 4,737,462

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Bayer Healthcare Pharms BETASERON interferon beta-1b VIAL; SUBCUTANEOUS 103471 001 1993-07-23 ⤷  Free Forever Trial Cetus Corporation (Emeryville, CA) 2005-04-12 RX Orphan company
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 4,737,462

Country Patent Number Estimated Expiration
South Africa 837789 ⤷  Free Forever Trial
United States of America 4518584 ⤷  Free Forever Trial
United States of America 4588585 ⤷  Free Forever Trial
United States of America 4853332 ⤷  Free Forever Trial
United States of America RE33653 ⤷  Free Forever Trial
Portugal 77512 ⤷  Free Forever Trial
Philippines 20343 ⤷  Free Forever Trial
>Country >Patent Number >Estimated Expiration

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