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Last Updated: October 6, 2022

Patent: 4,710,583


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Summary for Patent: 4,710,583
Title: Dipeptides and process
Abstract:Synthesis of phenylserine ester (a) via benzaldehyde and glycine ester using serine hydroxymethyltransferase; and (b) via methyl benzoylacetate. Synthesis of hydroxy-aspertame or derivative by enzymatic coupling of phenylserine or derivative with aspertic acid or derivative. Hydrogenation of the coupled product to give as final product aspertame or analog with related processes and products.
Inventor(s): Chmurny; Alan B. (Frederick, MD), Gross; Akiva T. (Rockville, MD), Kupper; Robert J. (Mount Airy, MD), Roberts; Rowena L. (Derwood, MD)
Assignee: W. R. Grace & Co. (New York, NY)
Application Number:06/789,595
Patent Claims:see list of patent claims

Details for Patent 4,710,583

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Smith & Nephew, Inc. SANTYL collagenase Ointment 101995 06/04/1965 See Plans and Pricing 2039-03-29
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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