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Last Updated: May 30, 2020

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Patent: 4,710,583

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Summary for Patent: 4,710,583
Title: Dipeptides and process
Abstract:Synthesis of phenylserine ester (a) via benzaldehyde and glycine ester using serine hydroxymethyltransferase; and (b) via methyl benzoylacetate. Synthesis of hydroxy-aspertame or derivative by enzymatic coupling of phenylserine or derivative with aspertic acid or derivative. Hydrogenation of the coupled product to give as final product aspertame or analog with related processes and products.
Inventor(s): Chmurny; Alan B. (Frederick, MD), Gross; Akiva T. (Rockville, MD), Kupper; Robert J. (Mount Airy, MD), Roberts; Rowena L. (Derwood, MD)
Assignee: W. R. Grace & Co. (New York, NY)
Application Number:06/789,595
Patent Claims:see list of patent claims

Details for Patent 4,710,583

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial W. R. Grace & Co. (New York, NY) 2039-03-29 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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