Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
Tetracyclines having substantially no effective antibiotic or antibacterial activity and possessing anti-collagen-destructive enzyme activity or anti-collagenase activity and compositions containing the same have been found useful as anti-collagenolytic agents. Such tetracyclines and compositions containing the same are useful in the treatment of periodontal diseases, corneal ulcers, bone deficiency disorders, rheumatoid arthritis diseases characterized by excessive collagen destruction. A special aspect of this invention involves the incorporation of such tetracyclines in animal feed compositions for improved animal nutrition, such as may be evidenced by increased weight gain.
McNamara; Thomas F. (Port Jefferson, NY), Ramamurthy; Nungavaram S. (Smithtown, NY), Golub; Lorne M. (Smithtown, NY)
The Research Foundation of State University of New York (Albany, NY)
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