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Last Updated: September 28, 2020

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Patent: 4,649,049

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Summary for Patent: 4,649,049
Title: Rabies vaccine
Abstract:A rabies vaccine composition is disclosed which comprises a sterilized suspension of proteineous suckling mice or rat brain particles of injectable particle size laden with an amount of inactivated rabies virus which is equivalent to a virus titer of at least 10.sup.5.0 to about 10.sup.6 MLD.sub.50 per 0.1 milliliter thereof at a brain tissue concentration of from about 0.3% to about 5.0% by weight, in physiological buffer solution having a pH of between about 7.5 and about 8.0 and comprising an amount dissolved therein, of between 0.02 and 0.08, preferably 0.04, moles per liter, of a buffer composition comprising a mixture of an organic base formula ##STR1## wherein R.sub.1 and R.sub.2 each are CH.sub.2, C.sub.2 H.sub.4 or C.sub.3 H.sub.6, preferably C.sub.2 H.sub.4 combined with between 0.03 and 0.12, preferably 0.06 moles per liter of its corresponding salt, preferable sodium salt. The presence of ethylene maleic anhydride enhances the effectiveness of the composition. The vaccine composition exhibits a high potency and its pH value remains stable over a prolonged period of time.
Inventor(s): Wilson; Jan S. (Fort Dodge, IA)
Assignee: American Home Products Corporation (New York, NY)
Application Number:06/629,307
Patent Claims:see list of patent claims

Details for Patent 4,649,049

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Glaxosmithkline Biologicals Sa RABAVERT rabies vaccine KIT 103334 1 2016-12-19   Start Trial American Home Products Corporation (New York, NY) 2040-01-28 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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