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Patent: 4,621,053

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Summary for Patent: 4,621,053

Title:	Process for the production of human peptide hormones
Abstract:	Human peptide hormones, such as insulin, growth hormone, prolactin, adrenocorticotropic hormone, placental lactogen, calcitonin, parathyroid hormone and thyroid stimulating hormone, are produced by implanting a human.times.human hybridoma lymphoblastoid cell line capable of producing the human peptide hormone in a non-human warm-blooded animal. After a period of time, the resultant tumor is extracted and disaggregated and then cultured in vitro under conditions appropriate to accumulate the human peptide hormone. The human.times.human hybridoma lymphoblastoid cell line is preferably formed by fusing parent human cells inherently capable of producing the human peptide hormone with a human lymphoblastoid line, preferably of leukemic origin. This process permits a substantial increase in the amount of human peptide hormone which can be produced.
Inventor(s):	Sugimoto; Kaname (Okayama, JP)
Assignee:	Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (Okayama, JP)
Application Number:	06/584,017
Patent Claims:	see list of patent claims

Details for Patent 4,621,053

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Estimated Patent Expiration	Status	Orphan	Source
Baxter Hlthcare Corp	MYXREDLIN	insulin human	SOLUTION;INTRAVENOUS	208157	001	2019-06-20		Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (Okayama, JP)	2000-07-30	RX		search
Nps Pharms Inc	NATPARA	parathyroid hormone	INJECTABLE;INJECTION	125511	004	2015-01-23		Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (Okayama, JP)	2000-07-30	RX	Orphan	search
Nps Pharms Inc	NATPARA	parathyroid hormone	INJECTABLE;INJECTION	125511	003	2015-01-23		Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (Okayama, JP)	2000-07-30	RX	Orphan	search
Nps Pharms Inc	NATPARA	parathyroid hormone	INJECTABLE;INJECTION	125511	002	2015-01-23		Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (Okayama, JP)	2000-07-30	RX	Orphan	search
Nps Pharms Inc	NATPARA	parathyroid hormone	INJECTABLE;INJECTION	125511	001	2015-01-23		Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (Okayama, JP)	2000-07-30	RX	Orphan	search

International Patent Family for US Patent 4,621,053

Country	Patent Number	Estimated Expiration
South Korea	830005866
South Korea	830005867
South Korea	830005868
South Korea	830007085
South Korea	830007086