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Last Updated: September 28, 2020

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Patent: 4,621,053

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Summary for Patent: 4,621,053
Title: Process for the production of human peptide hormones
Abstract:Human peptide hormones, such as insulin, growth hormone, prolactin, adrenocorticotropic hormone, placental lactogen, calcitonin, parathyroid hormone and thyroid stimulating hormone, are produced by implanting a human.times.human hybridoma lymphoblastoid cell line capable of producing the human peptide hormone in a non-human warm-blooded animal. After a period of time, the resultant tumor is extracted and disaggregated and then cultured in vitro under conditions appropriate to accumulate the human peptide hormone. The human.times.human hybridoma lymphoblastoid cell line is preferably formed by fusing parent human cells inherently capable of producing the human peptide hormone with a human lymphoblastoid line, preferably of leukemic origin. This process permits a substantial increase in the amount of human peptide hormone which can be produced.
Inventor(s): Sugimoto; Kaname (Okayama, JP)
Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (Okayama, JP)
Application Number:06/584,017
Patent Claims:see list of patent claims

Details for Patent 4,621,053

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Lilly HUMULIN R insulin recombinant human INJECTABLE;INJECTION 018780 001 1982-12-02   Start Trial Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (Okayama, JP) 2000-07-30 RX search
Lilly HUMULIN R KWIKPEN insulin human SOLUTION;SUBCUTANEOUS 018780 002 1982-12-02   Start Trial Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (Okayama, JP) 2000-07-30 RX search
Lilly HUMULIN R insulin human SOLUTION;SUBCUTANEOUS 018780 004 1982-12-02   Start Trial Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (Okayama, JP) 2000-07-30 RX search
Lilly HUMULIN R PEN insulin recombinant human INJECTABLE;INJECTION 018780 005 1982-12-02   Start Trial Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (Okayama, JP) 2000-07-30 RX search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (Okayama, JP) 2000-07-30 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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