Patent: 4,621,053

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Summary for Patent: 4,621,053

Title:	Process for the production of human peptide hormones
Abstract:	Human peptide hormones, such as insulin, growth hormone, prolactin, adrenocorticotropic hormone, placental lactogen, calcitonin, parathyroid hormone and thyroid stimulating hormone, are produced by implanting a human.times.human hybridoma lymphoblastoid cell line capable of producing the human peptide hormone in a non-human warm-blooded animal. After a period of time, the resultant tumor is extracted and disaggregated and then cultured in vitro under conditions appropriate to accumulate the human peptide hormone. The human.times.human hybridoma lymphoblastoid cell line is preferably formed by fusing parent human cells inherently capable of producing the human peptide hormone with a human lymphoblastoid line, preferably of leukemic origin. This process permits a substantial increase in the amount of human peptide hormone which can be produced.
Inventor(s):	Sugimoto; Kaname (Okayama, JP)
Assignee:	Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (Okayama, JP)
Application Number:	06/584,017
Patent Claims:	see list of patent claims

Details for Patent 4,621,053

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Eli Lilly And Company	HUMULIN R U-100	insulin human	Injection	018780	10/28/1982	See Plans and Pricing	2000-07-30
Eli Lilly And Company	HUMULIN R U-500	insulin human	Injection	018780	12/29/2015	See Plans and Pricing	2000-07-30
Eli Lilly And Company	HUMULIN R U-100	insulin human	Injection	018780	08/06/1998	See Plans and Pricing	2000-07-30
Eli Lilly And Company	HUMULIN R U-500	insulin human	Injection	018780	03/31/1994	See Plans and Pricing	2000-07-30
Eli Lilly And Company	HUMULIN R U-100	insulin human	Injection	018780	05/25/2018	See Plans and Pricing	2000-07-30
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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